Possible endorphin role in the anxiolytic/hypotensive action of taurine

I’ve been away from the computer for a while. I’ve been opium-free the last few weeks after an unremarkable taper. It wasn’t without some PAWS that was alleviated with a few supplements and other help. It’s all good now, though I don’t think I could have done it cold-turkey. I’ll probably titrate back up in a month or so.

I’m making a cd, so my interests lie elsewhere for now. I’m bored and burnt-out with blogging about EDS and everything around it, I’ve got a handle on it and there’s a big world with lots to do.

…anyway, I’ve been experimenting with calming supplements, some of which I’ve narrowed down that actually work! Myo-inositol is a b vitamin-like supp that can be found in the herb shop or on-line. This stuff works, and works well for PAWS anxiety… I actually can’t believe it, seeing that most supps are placebo junk. I take 20 gms as needed (6’2″ male). It works so well, I almost expect a banning of this by our elected thugs.

I’m not sure yet about GABA. If I take a large dose I get side-effects (niacin-like flush and face and chest itching), so something is happening despite that they say it can’t cross the blood-brain barrier, but I can’t figure out if it makes me feel good.

L-taurine is interesting because of its possible endorphin activation in rats. It promotes calmness and a hypotensive effect in humans, so I don’t doubt endogenous opioid actions in us either… I know it works for me.

…So that’s it for now. My next post will deal with the dynorphin/fat connection.


3 Comments (+add yours?)

  1. ItsTheWoo
    Feb 19, 2012 @ 21:23:49

    Good to hear from you and glad you are doing well; I was just wondering where you went to :)

    I have recently found, at least for myself while on a ketogenic diet/at night before an overnight fast, that a few grams of L-glutamine seems to have a clearly GABAergic effect. L-glutamine can pass the BBB, whereas glutamate and GABA can not. Much glutamine will end up as GABA.

    Some individuals may end up dumping glutamine into excitatory NTs like glutamate , aspartate, which would be the polar opposite of GABA, but it would be worth to try the L-glutamine to see if you are one who gets a GABA effect. I clearly do.


  2. Opie
    Feb 20, 2012 @ 11:15:26

    hi Wooo. thanks. you’re sweet.

    i have bad reactions with excitatory aminos (as you know), but i’ll give it a shot and let you know how it goes.


  3. Vieno
    Oct 31, 2012 @ 10:38:34

    What’s up Poppy, you still around? I’d like to have a word with you about all this. How can I get in touch with you?


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